Chord resonance is at the heart of temperaments. A great site to get some perspective about this is Carey Beebe Harpsichords.
www.hpschd.nu/index.html?nav/nav-4.html ... p/faq.html
Harpsichords use notes and chords too .The site discusses tuning details of 31 temperaments and how well or not they can modulate . Just skim past the tuning details and you can learn a lot .He has a nice sense of humour and a direct Australian style.
This guitar forum has been lost in the wilderness and needs some decent music history to fill up a huge gap .
I have to warn you he talks about Evil Temperament and seems to have a swing at the Jiulliard School of Music too . Nice one Carey .
One of the temperaments Carey Beebe tuned on a harpsichord was requested for a duet with a flute . Another temperament was well suited to accompany a violin . It`s not such a bad idea to explore the ways a guitar sound can be improved . The outer limits so far seem to extend to pretty tuning machines and double tops that shift the guitar sound a bit further than many people like.